The main research fields of BioIRC are biomedical simulations and experiments regarding this field.

 Presentation of research results of BioIRC in biomechanics includes:

A. NUMERICAL SIMULATIONS

BLOOD FLOW THROUGH AN ANEURYSM (MedCFD Demo v1.0b, downloadable)

1. Demo version of the general CFD software for application in medicine 

BLOOD FLOW THROUGH BLOOD VESSELS WITH DEFORMABLE WALLS AND ARTIFICIAL HEART DEVICE

1. Three-dimensional CFD simulation of flow through blood vessels
2. Wall shear stress computation
3. Deformable walls, Fluid-structure interaction
4. Nonlinear behaviour of deformable walls
5. Blood flow in the human aorta, aortic bifurcation, carotid artery bifurcation, coronary artery branch
6. Fluid dynamics phenomena of blood flow in the heart

NUMERICAL SIMULATION OF MASS TRANSPORT AND EXCHANGE PROCESSES IN THE BLOOD VESSELS

1. Transport of macromolecules
2. Development of atherosclerosis
3. Convective diffusive arterial mass transfer
4. Oxygen transport in blood and in the arterial wall

FINITE ELEMENT ANALYSIS OF SCELETAL MUSCLES

1. Basic Hill's three-componental model of muscle within finite element analysis
2. Modeling of passive and active conditions, activation function

    Applications: Soft palate, frog gastrocnemius muscle.

CARTILAGE BIOMECHANICS

1. Viscoelastic behaviour and creep
2. 3-D model of cartilage

Swelling effect: water content, ion concentration, electrokinetic coupling
    Applications:

1. Spinal motions segment-intervertebral disc
2. Intradiscal pressure, change in water content, mechanical stress, swelling pressure, fluid pressure, displacement of the solid, relative velocity of the fluid, electrical potential
3. Mechanical response of a lumbar motion segment in axial torque combined with compression
4. Complex spinal loads during dynamic lifting tasks

RESPIRATORY SYSTEM

1. Numerical simulation of air flow in the respiratory system
2. Flow in the alveolated duct
3. Particle tracking and particle deposition
4. Software package CFDAL for modeling of alveolated flow

B. EXPERIMENTAL RESEARCH

1. Development of artificial heart device, automatic control of parameters: frequency, volumetric flow, pressure
2. Effects of biological active molecules (histamine, histamine derivatives, glucagon etc.) on the isolated blood vessels and the isolated heart
3. Transport studies in the isolated heart
4. Development of “Stretch system” for determination and further investigation of mechanical characteristics and functional properties of various tissue , such as: visceral organs walls (urinary bladder wall, gastric, duodenal and intestine wall) and blood vessels (arteries and veins)
5. Variation of strain rate, relaxation behavior
6. Definition of mechanical models

     
*REFERENCES